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目的观察米非司酮联合依沙吖啶用于中期妊娠引产的疗效。方法将孕14～17周因妊娠合并症或计划外怀孕自愿要求终止妊娠的96例患者,随机分为2组:观察组48例,依沙吖啶100mg羊膜腔内注射,同时口服米非司酮50mg,间隔12h再服米非司酮50mg,最大量150mg。对照组48例,单用依沙吖啶100mg羊膜腔内注射。结果宫腔注药至宫缩发动时间、成功率差异无统计学意义(P>0.05)。宫腔注药至胎儿娩出时间、总产程、产后2h出血量、清宫率、宫腔注药24h后宫颈变化、软产道损伤均差异有统计学意义(P<0.01)。结论米非司酮联合依沙吖啶中期妊娠引产有协同作用,能明显缩短引产时间,减少清宫率,临床上是一种较好的终止中期妊娠的方法。
Objective To observe the efficacy of mifepristone combined with ethacridine in induction of labor during midterm pregnancy. Methods A total of 96 pregnant women with gestational complications or unplanned pregnancies requiring termination of pregnancy were randomly divided into two groups: 48 in the observation group, 100 in the amniotic cavity injected with ethacridine, Ketone 50mg, interval 12h and then taking mifepristone 50mg, the maximum amount of 150mg. The control group of 48 patients, single with acridine acridine 100mg amniotic cavity injection. Results uterine injection to the time of uterine contractions, the success rate difference was not statistically significant (P> 0.05). Intrauterine injection of drugs to the time of delivery of the fetus, total labor, 2h postpartum hemorrhage, clearance rate, intrauterine injection 24h after cervical changes, soft birth canal injury were significantly different (P <0.01). Conclusion Mifepristone combined with ethacridine in the second trimester induction of labor has a synergistic effect, can significantly shorten the time of induction of labor, reduce the curettage rate, clinically a better way to terminate the second trimester pregnancy.