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目的:探讨急性腹泻患儿治疗中血锌水平检测的临床意义,为小儿急性腹泻的监控与预防提供理论依据。方法:选取2012年8月~2013年8月在该院就诊的急性腹泻患儿64例为病例组,另选取同期在该院体检的健康儿童30例为对照组。病例组患儿在急性腹泻常规治疗的基础上加用葡萄糖酸锌口服液口服治疗。分别检测两组儿童就诊时和治疗7天后的血锌水平。比较两组儿童的血锌水平和病例组治疗前后的血锌水平,并观察病例组患儿的临床治疗效果。结果:病例组治疗前各年龄段患儿血锌水平均显著低于对照组,差异有统计学意义(P<0.05)。治疗后,病例组各年龄段患儿的血锌水平均显著高于治疗前,差异有统计学意义(P<0.05),与对照组比较差异无统计学意义(P>0.05);病例组患儿显效43例、有效17例,总有效率为93.75%。结论:急性腹泻患儿存在一定程度的锌缺乏,临床治疗中应重视改善锌缺乏状态,进一步提高该病的临床治疗效果。
Objective: To investigate the clinical significance of blood zinc level in the treatment of children with acute diarrhea and provide the theoretical basis for the monitoring and prevention of acute diarrhea in children. Methods: Sixty-four children with acute diarrhea admitted to the hospital from August 2012 to August 2013 were selected as the case group. Thirty healthy children were selected as the control group during the same period. Cases of children with acute diarrhea based on the conventional treatment plus oral gluconate oral treatment. Blood zinc levels were measured at the time of treatment and after 7 days of treatment in both groups. Blood zinc levels were compared between the two groups of children and before and after treatment in patients with zinc levels, and to observe the clinical treatment of children in the case group. Results: The blood zinc level of children in each age group before treatment was significantly lower than that of the control group (P <0.05). After treatment, the levels of zinc in children of all age groups were significantly higher than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05) Children markedly effective in 43 cases, effective in 17 cases, the total effective rate was 93.75%. Conclusion: There is a certain degree of zinc deficiency in children with acute diarrhea. In clinical treatment, zinc deficiency should be improved and the clinical effect of the disease should be further improved.