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实验观察和比较了1.9％复方盐酸普鲁卡因、普鲁卡因和利多卡因对蟾蜍坐骨神经动作电位传导速度的影响。结果表明:三种不同的麻醉剂在给药后1～6分钟内均可明显抑制动作电位的传导速度,并随时间推移其抑制作用逐渐加强。1.9％复方盐酸普鲁卡因与同浓度普鲁卡因相比在4～6分钟,前者抑制作用的速度明显快于后者(P<0.05)。与同浓度利多卡因相比无明显差异(P>0.05)。结果提示:1.9％复方盐酸普鲁卡因可通过抑制动作电位传导速度而达到神经阻滞麻醉的目的,同时证明,它的作用效力强于普鲁卡因,与利多卡因的作用效力相近。
The effects of 1.9% procaine hydrochloride, procaine and lidocaine on conduction velocity of sciatic nerve in toads were observed and compared. The results showed that the three different anesthetics could significantly inhibit the conduction velocity of action potential within 1 to 6 minutes after administration, and their inhibitory effects gradually strengthened over time. 1.9% procaine hydrochloride compound with the same concentration of procaine in 4 to 6 minutes, the former inhibition rate was significantly faster than the latter (P <0.05). Compared with the same concentration of lidocaine no significant difference (P> 0.05). The results suggest that: 1.9% compound procaine hydrochloride can inhibit the action potential conduction velocity to achieve the purpose of nerve block anesthesia, at the same time, it proved that its effectiveness is stronger than procaine, similar to the potency of lidocaine.