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目的探讨结直肠癌组织中p27、cyclinD1的表达及其在预后方面的价值。方法采用免疫组化的方法检测61例结直肠癌组织中p27、cyclinD1的表达,分析其表达与临床病理学特征和预后的关系及两者之间的相关性。结果结直肠癌组p27和cyclinD1表达分别是72.13%、45.90%,p27的表达与组织分化、淋巴结转移、临床分期呈负相关,p27阴性者5年生存率(38.24%)明显低于p27阳性者(81.64%);而cyclinD1的表达与组织分化、淋巴结转移、临床分期、浸润深度呈正相关,cyclinD1阴性者5年生存率(78.46%)明显高于cyclinD1阳性者(59.63%)。结直肠癌组织中两者表达呈负相关。结论 p27的缺失和cyclinD1的过表达与结直肠癌5年生存率低有关,提示两者可以作为结直肠癌的预后指标之一。
Objective To investigate the expression of p27 and cyclinD1 in colorectal cancer and its prognostic value. Methods The expression of p27 and cyclinD1 in 61 colorectal cancer tissues was detected by immunohistochemistry. The relationship between the expression of p27 and cyclinD1 and the clinicopathological features and prognosis was analyzed. Results The expressions of p27 and cyclinD1 in colorectal cancer were 72.13% and 45.90% respectively. The expression of p27 was negatively correlated with tissue differentiation, lymph node metastasis and clinical stage. The 5-year survival rate (38.24%) of p27 negative was significantly lower than that of p27 (81.64%). The expression of cyclinD1 was positively correlated with tissue differentiation, lymph node metastasis, clinical stage and depth of invasion. The 5-year survival rate (78.46%) of cyclinD1-negative patients was significantly higher than that of cyclinD1-positive patients (59.63%). Colorectal cancer tissue expression was negatively correlated. Conclusion The deletion of p27 and the overexpression of cyclinD1 are associated with the low 5-year survival rate of colorectal cancer, suggesting that they may serve as one of the prognostic indicators of colorectal cancer.