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在肝纤维化发病机制的研究中,一个基本尚未解决的问題是哪些细胞产生胶原纤维。以往普遍认为肝脏和体内其他大多数组织一样,胶原纤维大都由纤维母细胞产生,储脂细胞也可产生胶原纤维。但仍有一些问题据此不能解释。虽然从体外实验结果可以推测肝细胞能够产生胶原纤维,但肝细胞在原位能否产生胶原纤维还未确定。因此,重要的是要找到直接证据,证实哪种细胞在肝內参与了胶原纤维的形成。中国医学科学院药物研究所肝炎
In the study of the pathogenesis of liver fibrosis, a fundamental unsolved problem is which cells produce collagen fibers. In the past generally believed that the liver and most other body tissues, like collagen fibers are mostly produced by fibroblasts, fat-storing cells can also produce collagen fibers. However, there are still some problems that can not be explained. Although in vitro experiments suggest that liver cells can produce collagen fibers, whether or not hepatocytes produce collagen fibers in situ has not been determined. Therefore, it is important to find direct evidence of which cells are involved in collagen formation in the liver. Institute of Materia Medica, Chinese Academy of Medical Sciences, Hepatitis