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目的探讨血管转化生长因子β1(TGF-β1)和白细胞介素-6(IL-6)在新生儿肺炎患儿血清中的表达及其临床意义。方法应用酶联免疫吸附法(ELISA)检测40例新生儿肺炎患儿和30名健康新生儿血清TGF-β1和IL-6的水平。结果患儿血清TGF-β1水平肺炎组(12.87pg/ml)低于对照组(37.17pg/ml)(P<0.01),IL-6水平肺炎组(59.27pg/ml)高于对照组(21.58pg/ml)(P<0.01)。患儿血清TGF-β1水平重症肺炎(7.65pg/ml)低于轻症肺炎患儿(21.57pg/ml)(P<0.01),IL-6水平重症患儿(73.65pg/ml)高于轻症肺炎患儿(35.31pg/ml)(P<0.01)。血清TGF-β1水平急性期患儿(4.12pg/ml)低于恢复期患儿(23.57pg/ml)(P<0.01),IL-6水平急性期患儿(76.42pg/ml)高于恢复期(38.31pg/ml)(P<0.01)。结论 TGF-β1和IL-6在新生儿肺炎患儿血清中异常表达,其水平与患儿病情严重程度相关。血清TGF-β1和IL-6联合检测对患儿病情有着重要的临床意义。
Objective To investigate the expression of serum transforming growth factor-β1 (TGF-β1) and interleukin-6 (IL-6) in serum of children with neonatal pneumonia and its clinical significance. Methods Serum levels of TGF-β1 and IL-6 in 40 neonates with pneumonia and 30 healthy newborns were detected by enzyme linked immunosorbent assay (ELISA). Results Serum TGF-β1 pneumonia group (12.87pg / ml) was lower than the control group (37.17pg / ml) (P <0.01), IL-6 pneumonia group pg / ml) (P <0.01). Serum levels of TGF-β1 in children with severe pneumonia (7.65pg / ml) were significantly lower than those with mild pneumonia (21.57pg / ml) (P <0.01) Children with symptomatic pneumonia (35.31 pg / ml) (P <0.01). Serum levels of TGF-β1 in acute stage (4.12pg / ml) were lower than those in convalescent stage (23.57pg / ml) (P <0.01) (38.31 pg / ml) (P <0.01). Conclusion TGF-β1 and IL-6 are abnormally expressed in the serum of children with neonatal pneumonia. The levels of TGF-β1 and IL-6 are correlated with the severity of the disease in children. Serum TGF-β1 and IL-6 combined detection of the disease in children has an important clinical significance.