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在常温下长时程阻断一侧肺动脉主干作肺叶切除病例２０ 例，１０ 例为预处理组，１０ 例为对照组。结果提示：预处理组血中降钙素基因相关肽（ Ｃ Ｇ Ｒ Ｐ） 、超氧化物歧化酶（ Ｓ Ｏ Ｄ） 及肺静脉氧分压（ Ｐｐｖ Ｏ２）较对照组明显增加（ Ｐ ＜ ０ ．０５） ，而血中丙二醛（ Ｍ Ｄ Ａ） 含量及肺平均动脉压（ Ｍ Ｐ Ａ Ｐ） 较对照组明显降低（ Ｐ＜ ０ ．０５） 。提示缺血预处理能减轻在体肺缺血再灌注损伤，其机制可能与内源性降钙素基因相关肽产生增加有关。
At room temperature, 20 cases of lobectomy were treated with long-term blocking of the main pulmonary artery, 10 cases were pretreatment group and 10 cases were control group. The results suggest that the blood levels of calcitonin gene-related peptide (CRP), superoxide dismutase (SOD), and pulmonary vein oxygen pressure (PpvO2) in the pretreatment group were significantly higher than those in the control group (P < 0. 05) , and blood malondialdehyde (MDA) content and mean pulmonary arterial pressure (MAPA P) were significantly lower than those in the control group (P < 0.05). It is suggested that ischemic preconditioning can reduce the lung ischemia-reperfusion injury in vivo, and the mechanism may be related to the increase of endogenous calcitonin gene-related peptide production.