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本实验采用~3H-TdR参入-高速放射自显影和脾结节生成技术等现代实验血液学方法,对苯中毒时骨髓细胞的功能变化进行了动态观察,并比较了不同苯剂量对其骨髓毒性的影响。 结果表明,轻度苯中毒时,其骨髓毒性可能主要由于骨髓分化细胞DNA的合成受到干扰而引起,骨髓造血微环境可能也受到波及。 本文还讨论了苯中毒的临床发病机理。认为苯中毒可能会损及包括造血干细胞和造血微环境在内的骨髓所有成分;苯的作用强度则可能是此种毒性作用的关键,使得苯中毒具有延续性、多样性和可逆性的临床特点。
In this study, 3H-TdR incorporation - high-speed autoradiography and splenic nodule generation techniques and other modern experimental hematology methods were used to observe the functional changes of bone marrow cells during benzene poisoning and to compare the different doses of benzene on their bone marrow toxicity Impact. The results showed that mild benzene poisoning, the myelotoxicity may be mainly due to bone marrow cells differentiated DNA synthesis caused by interference caused by bone marrow hematopoietic microenvironment may also be affected. This article also discusses the clinical pathogenesis of benzene poisoning. Benzene poisoning is believed to impair all components of the bone marrow, including hematopoietic stem cells and hematopoietic microenvironment; the strength of benzene may be the key to this toxic effect, making clinical manifestations of continuity, diversity and reversibility of benzene poisoning .