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血管利钠肽（ＶＮＰ）是新近人工合成的由２７个氨基酸残基组成的肽类物质，它是心房利钠利尿肽（ＡＮＰ）和Ｃ型利钠利尿肽（ＣＮＰ）的杂交物。我们采用离体血管灌流的方法观察了ＶＮＰ对离体大鼠肺动脉和腹主动脉的舒张作用。表明ＶＮＰ对内皮完整的与去内皮的肺动脉和腹主动脉均有浓度依赖性舒张作用，其对抗去甲肾上腺素（１０μｍｏｌ／Ｌ）或ＫＣｌ（６０ｍｍｏｌ／Ｌ）收缩肺动脉的最大舒张效应明显大于腹主动脉；内皮完整和去内皮组之间无显著性差异；在浴槽内预先加入优降糖可显著减低肺动脉和腹主动脉对ＶＮＰ的舒血管效应，预先加入心得安则不明显影响ＶＮＰ对肺动脉和腹主动脉的舒血管作用。提示ＶＮＰ对上述血管的舒张作用不依赖于内皮的存在，但受ＡＴＰ敏感性钾通道的调控
Vascular Natriuretic Peptide (VNP) is a newly synthesized peptide consisting of 27 amino acid residues that is a hybrid of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). We observed the vasodilation effect of VNP on pulmonary artery and abdominal aorta in isolated rat by using the method of ex vivo vascular perfusion. The results showed that VNP had a concentration-dependent relaxation effect on endothelial integrity and endothelium-dependent pulmonary artery and abdominal aorta. The maximal relaxation effect of VNP against pulmonary arteries contracting norepinephrine (10μmol / L) or KCl (60mmol / L) There was no significant difference between intact endothelium and endothelium. Pretreatment with glibenclamide in the bath significantly reduced the vasorelaxation effects of pulmonary artery and abdominal aorta on VNP. Preaddition of propranolol did not significantly affect the effect of VNP on pulmonary artery And vasodilator effects of the abdominal aorta. It is suggested that the vasodilatation effect of VNP on these blood vessels does not depend on the existence of endothelial cells but is regulated by the ATP-sensitive potassium channel