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目的:观察益肾固精汤对系膜增生性肾炎患者TGF-β1的表达并探讨其在系膜增生性肾炎中的作用机理。方法:将60例患者随机分为肾炎对照组、苯那普利组和中药治疗组各20例,另选择20例健康志愿者为正常对照组。肾炎对照组采用肾炎常规基本用药,即利尿降压等对症治疗;苯那普利组采用常规基本用药加苯那普利片10mg∕d;中药治疗组采用肾炎常规基本用药加益肾固精汤,用双抗体夹心ELISA法检测血清TGF-β1水平。结果:系膜增生性肾炎患者各组TGF-β1表达明显高于健康对照组(P<0.01);TGF-β1治疗前后比较,肾炎对照组治疗后TGF-β1表达无明显差异((P>0.05),苯那普利组和中药治疗组TGF-β1表达较治疗前明显下降(P<0.05),但两组比较无明显差异((P>0.05)。结论:益肾固精汤可能具有抑制肾脏纤维化,从而达到减轻肾脏病理损害,减少蛋白尿的作用。
Objective: To observe the effect of Yishen Gujing Decoction on the expression of TGF-β1 in mesangial proliferative glomerulonephritis and explore its mechanism in mesangial proliferative glomerulonephritis. Methods: Sixty patients were randomly divided into nephritis control group, benazepril group and traditional Chinese medicine treatment group, 20 cases each. Another 20 healthy volunteers were selected as normal control group. Nephritis control group using nephritis routine basic medication, namely, diuretic antihypertensive symptomatic treatment; benazepril group with conventional basic treatment plus benazepril tablets 10mg / d; traditional Chinese medicine treatment group with nephritis conventional basic treatment plus Yishen Gujing Decoction The level of serum TGF-β1 was detected by double antibody sandwich ELISA. Results: The expression of TGF-β1 in mesangial proliferative glomerulonephritis group was significantly higher than that in healthy control group (P <0.01). There was no significant difference in the expression of TGF-β1 before and after TGF-β1 treatment ), And benazepril and Chinese medicine treatment group, the expression of TGF-β1 was significantly lower than that before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05) .Conclusion: Yishen Gujing Decoction may have inhibitory effect Kidney fibrosis, so as to reduce renal pathological damage, reduce the role of proteinuria.