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本发明属于化合物的合成方法,具体涉及一种1,2-二取代-5-磺酰基咪唑类化合物的制备方法。所述1,2-二取代-5-磺酰基咪唑类化合物的制备方法,是以通式III化合物经5位磺酰化反应获得的通式IV化合物,反应方程式如下:其中R1为烷基或环烷基;R2为烷基或芳基;R3为烷基或芳基。本发明提供的技术方案通过三步反应合成目标产物,总产率超过50%,为前述文献方法
The present invention belongs to a method for synthesizing a compound, in particular to a method for preparing a 1,2-disubstituted-5-sulfonylimidazole compound. The preparation method of the 1,2-disubstituted-5-sulfonylimidazole compound is that the compound of the general formula IV is obtained by sulfonylation reaction of the compound of the general formula III through 5-position, and the reaction formula is as follows: wherein R1 is an alkyl group or Cycloalkyl; R2 is alkyl or aryl; and R3 is alkyl or aryl. The technical proposal provided by the invention synthesizes the target product through a three-step reaction, and the total yield is more than 50%