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[目的]探讨TP和COX-2在胃癌中的表达及其临床意义。[方法]采用免疫组化方法检测TP和COX-2在50例胃癌中的表达,分析其与胃癌临床病理特征及预后的关系。[结果]TP和COX-2在胃癌中的阳性表达率分别为56.0%(28/50)和62.0%(31/50)。TP蛋白表达与胃癌的分化程度、浸润深度和淋巴结转移相关(P<0.05);COX-2蛋白表达与胃癌淋巴结转移相关(P<0.05)。胃癌组织中TP和COX-2的表达呈正相关(χ2=4.565,P<0.05)。TP表达阳性和阴性者的5年生存率分别为25.0%和54.5%(P<0.05);COX-2表达阳性和阴性者的5年生存率分别为22.6%和63.2%(P<0.05)。[结论 ]TP和COX-2在胃癌的发生发展中可能起重要作用,可作为预测胃癌预后的指标。
[Objective] To investigate the expression and clinical significance of TP and COX-2 in gastric cancer. [Methods] The expressions of TP and COX-2 in 50 cases of gastric cancer were detected by immunohistochemistry. The relationship between TP and COX-2 in clinicopathological features and prognosis of gastric cancer was analyzed. [Results] The positive rates of TP and COX-2 in gastric cancer were 56.0% (28/50) and 62.0% (31/50), respectively. The expression of TP protein was correlated with the degree of differentiation, depth of invasion and lymph node metastasis (P <0.05). The expression of COX-2 protein was correlated with the lymph node metastasis of gastric cancer (P <0.05). There was a positive correlation between the expression of TP and COX-2 in gastric cancer (χ2 = 4.565, P <0.05). The 5-year survival rates of TP positive and negative patients were 25.0% and 54.5% respectively (P <0.05). The 5-year survival rates of positive and negative patients with COX-2 expression were 22.6% and 63.2%, respectively. [Conclusion] TP and COX-2 may play an important role in the occurrence and development of gastric cancer, which can be used as an index to predict the prognosis of gastric cancer.