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目的分析我院近几年来抗感染药物不良反应(ADR)的发生情况,为临床安全、合理用药提供参考。方法对我院1999年1月～2007年10月ADR监测小组收集的159例抗感染药物ADR报告进行回顾性分类统计分析。结果159例ADR报告涉及药物12类41个品种,其中喹诺酮类药物报告例数为首位,其次为林可霉素类及青霉素类药物等。ADR的临床表现主要为皮肤及其附件损害最为多见,其次为消化系统损害和神经系统损害等。结论合理使用抗感染药物,重视ADR的监测工作,减少ADR发生。
Objective To analyze the occurrence of adverse drug reactions (ADRs) in our hospital in recent years and provide references for clinical safety and rational drug use. Methods A retrospective classification and statistical analysis of 159 cases of ADR reported by ADR monitoring team from January 1999 to October 2007 in our hospital was conducted. Results A total of 159 ADR cases were reported in 12 categories and 41 varieties. Among them, quinolones were the most frequently reported, followed by lincomycin and penicillin. The main clinical manifestations of ADR damage to the skin and its accessories most common, followed by digestive system damage and nervous system damage. Conclusion The rational use of anti-infective drugs, emphasis on monitoring of ADR, reduce the occurrence of ADR.