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目的 研究急性白血病患儿应用重组粒细胞集落刺激因子 (rhG CSF)后自身抗体的产生及其临床意义。方法 应用ELISA技术检测 10 4例正常儿童和 4 6例急性白血病患儿血清rhG CSF抗体。结果 共有 11例患儿在应用rhG CSF后检测到自身抗体 ,并均在 3个月内转阴。在抗体阴性和阳性组之间 ,rhG CFS疗程结束时的中性粒细胞数差异显著 (P <0 0 5 ) ,但与rhG CSF用量和病程无关。结论 应用rhG CSF诱导产生的自身抗体可抑制该制剂的生物学功能 ,监测抗体可预测rhG CSF对中性粒细胞的恢复效用。
Objective To study the production of autoantibodies after rhG CSF transplantation in children with acute leukemia and its clinical significance. Methods Serum rhG CSF antibody was detected by ELISA in 104 children and 46 children with acute leukemia. Results A total of 11 children with autoantibodies were detected after rhG CSF administration and were all negative within 3 months. The number of neutrophils at the end of rhG CFS treatment was significantly different between antibody negative and positive groups (P <0 05), but not with rhG CSF dosage and duration. Conclusions The autoantibodies induced by rhG CSF can inhibit the biological function of this preparation, and the monitoring antibody can predict the recovery of neutrophils by rhG CSF.