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目的：观察不同方案应用血管肽对大鼠颈动脉胶原酶内在剥脱术后肌内膜增殖的作用。方法：ＳＤ大鼠随机分为４组，经不同途径给药。１４ｄ取材测定内膜／中膜面积、厚度比值。结果：静脉组各值小于术前３０ｍｉｎ皮下用药组（ｑ＝５．３７２１，２４．５５５６；Ｐ＜０．０１）。对照与延滞皮下给药组各值无差异（ｑ＝２．２１８０，２．５３７０；Ｐ＞０．０５）。结论：静脉给药优于皮下注射法；延滞给药作用消失。提示其抗增殖作用与血管损伤后早期事件有关。
OBJECTIVE: To observe the effect of different application of vasopepsin on endometrial hyperplasia after carotid artery collagenase internal ablation in rats. Methods: SD rats were randomly divided into 4 groups and administered by different routes. 14d material determination of intima / media area, thickness ratio. Results: The values in the venous group were less than those in the subcutaneous group 30 minutes before operation (q = 5.3721,24.5556; P <0.01). There was no difference between the control group and the subcutaneous administration group (q = 2.2180,2.5370; P> 0.05). Conclusion: Intravenous administration is superior to subcutaneous injection; the effect of delayed administration disappears. Suggesting that its antiproliferative effect and vascular injury early events.