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视网膜色素变性 (retinitis pigmentosa,RP)是世界上最常见的遗传性致盲疾患之一。目前的研究表明 ,碱性成纤维细胞生长因子 (basic fibroblast growth factor,b FGF )可以挽救视网膜光感受器的变性。现将 b FGF的来源、生物学活性、在治疗视网膜变性疾病机制方面的研究进展以及采用 b FGF基因转移治疗 RP的研究现状等综述如下。
Retinitis pigmentosa (RP) is one of the most common hereditary blinding disorders in the world. The current research shows that basic fibroblast growth factor (b FGF) can save the degeneration of retinal photoreceptors. Now b FGF source, biological activity, in the treatment of retinal degenerative disease mechanism research progress and b FGF gene transfer treatment of RP research status are summarized below.