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目的 探讨环氧化酶 - 2 (COX - 2 )表达与膀胱癌生物学行为的关系及其意义。方法 采用免疫组化SABC法检测 5 4例膀胱癌、2 9例癌旁组织和 10例正常膀胱粘膜中的COX - 2表达 ,结合临床病理资料进行分析。结果 COX - 2在不同膀胱组织中的表达差异有显著性 (P <0 .0 5 ) ,即膀胱癌组织 >癌旁组织 >正常膀胱粘膜。COX - 2表达随膀胱癌病理级和临床分期的增加而增加 (P <0 .0 5、P <0 .0 1) ,且癌组织中COX - 2表达与淋巴转移有关 (P <0 .0 5 )。结论 COX - 2表达与膀胱癌病理分级、临床分期、淋巴转移有关 ,提示它可能在胱癌的发生、发展中扮演重要角色 ,通过抑制COX - 2活性可能为膀胱癌的防治提供新途径。
Objective To investigate the relationship between cyclooxygenase - 2 (COX - 2) expression and biological behavior of bladder cancer and its significance. Methods Immunohistochemical SABC method was used to detect the expression of COX - 2 in 54 cases of bladder cancer, 29 cases of paracancerous tissues and 10 cases of normal bladder mucosa. The clinicopathological data were used to analyze the expression of COX - 2. Results The expression of COX - 2 in different bladder tissues was significantly different (P <0.05), that is, the expression of COX - 2 in bladder cancer> paracancerous tissue> normal bladder mucosa. The expression of COX - 2 increased with the pathological grade and clinical stage of bladder cancer (P <0.05, P <0.01), and the expression of COX - 2 was correlated with lymph node metastasis (P <0. 0 5). Conclusions The expression of COX - 2 is correlated with the pathological grade, clinical stage and lymphatic metastasis of bladder cancer, suggesting that COX - 2 may play an important role in the occurrence and development of bladder cancer. It may provide a new way for the prevention and treatment of bladder cancer by inhibiting the activity of COX - 2.