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通过建立大鼠高血脂症动物模型,用不同剂量的自制大豆小肽灌胃大鼠,分别在第20,40,60天时尾静脉采血测定血液生化指标,并在第21天进行游泳负重实验和肝糖原含量测定,探讨了大豆低聚肽在调解血脂、预防动脉粥样硬化、抗疲劳作用。结果表明:灌胃60 d时高剂量组的大鼠的TC、TG、LDL-C、TXA2相对于模型对照组显著降低,分别降低22.97%、8%、15.29%、18.97%,高剂量组大鼠的NO、HDL-C、PGI2相对于模型对照组显著升高,分别升高了43.85%%、20.56%、28.92%。抗疲劳试验中,在灌胃剂量2.0 g·kg-1(体重)时,小鼠负重时间比对照组延长61.49%,小鼠肝糖原含量为20.07 mg·g-1,与对照组相比提高了41.14%。表明大豆小肽具有明显的预防动脉粥样硬化和抗疲劳的功能。
Animal models of hyperlipidemia in rats were established, and different doses of homemade small peptides were intragastrically administered to rats. Blood samples were taken from the tail vein on the 20th, 40th and 60th days respectively for blood biochemical analysis and swimming load test on the 21st day. Hepatic glycogen content determination, to explore soybean oligopeptide in the regulation of blood lipids, prevention of atherosclerosis, anti-fatigue effect. The results showed that the levels of TC, TG, LDL-C and TXA2 in the high-dose group decreased significantly by 22.97%, 8%, 15.29% and 18.97%, respectively, compared with the model control group The NO, HDL-C and PGI2 in rats increased significantly compared with the model control group, and increased by 43.85%, 20.56% and 28.92% respectively. In the anti-fatigue test, the weight-bearing time of mice was increased by 61.49% and the liver glycogen content of mice was 20.07 mg · g-1 at the dose of 2.0 g · kg-1 (body weight) compared with the control group Increased by 41.14%. Soybean peptides showed significant anti-atherosclerosis and anti-fatigue function.