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观察４０例慢乙肝用异体淋巴因子激活的杀伤细胞（ＬＡＫ细胞）治疗前后外周血Ｔ淋巴细胞亚群的变化，并与肝病对照组、正常对照组比较。结果发现慢乙肝患者ＣＤ＋３、ＣＤ＋４、ＣＤ＋８及ＣＤ＋４／ＣＤ＋８比值均明显低于正常对照组（Ｐ＜０．０５）。用ＬＡＫ细胞治疗后，观察组ＣＤ＋３、ＣＤ＋４和ＣＤ＋４／ＣＤ＋８比值比治疗前上升（Ｐ＜０．０５），接近正常对照组，ＣＤ＋４／ＣＤ＋８比值升高与ＣＤ＋４升高有关。ＣＤ＋８治疗前后均低于正常对照组。结果提示输ＬＡＫ细胞后，由于ＣＤ＋４细胞的增加，对机体免疫调节网络具有启动调节和促进作用。
The changes of T lymphocyte subsets in peripheral blood of 40 patients with chronic hepatitis B treated with allogeneic lymphokine-activated killer cells (LAK cells) were observed and compared with the control group and the normal control group. The results showed that the ratio of CD + 3, CD + 4, CD + 8 and CD + 4 / CD + 8 in patients with chronic hepatitis B were significantly lower than that of the normal control group (P <0.05). After treatment with LAK cells, the ratio of CD + 3, CD + 4 and CD + 4 / CD + 8 in the observation group increased compared with that before treatment (P <0.05), which was closer to the normal control group. CD + 8 before and after treatment were lower than the normal control group. The results suggest that LAK cells, due to the increase of CD + 4 cells on the body’s immune regulatory network with the start regulating and promoting effect.