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目的:评估丝裂霉素C(MMC)联合粘小管成形术治疗开角型青光眼的效果。方法:回顾性研究。收集2007-12/2014-03接受粘小管成形术患者104例122眼。记录术前术后眼内压(IOP),青光眼用药数量,视力,并发症,辅助治疗(激光前房角穿刺或青光眼用药)和成功率。IOP≤21 mmHg无额外用药为完全成功,IOP≤21 mmHg有或无青光眼用药为部分成功。结果:术前平均IOP为27.5±9.2 mmHg,术后平均IOP为14.5±6.6 mmHg(P<0.001)。术前平均视力为0.42±0.4,术后为0.32±0.4(P=0.726)。部分成功106眼(86.9%),完全成功62眼(50.8%)。激光前房角穿刺术43眼(35.2%),青光眼药物使用率为49.1%。术后平均随访27.29±16.78(1~79)mo。结论:粘小管成形术并发症发生率低且术后视力稳定,是一种安全的选择,术后补充进行激光前房角穿刺术可以提高手术成功率。丝裂霉素C对于粘小管成形术的作用还需进行深入的比较研究。
PURPOSE: To evaluate the efficacy of mitomycin C (MMC) in combination with tubuloplasty in the treatment of open-angle glaucoma. Methods: Retrospective study. A total of 122 eyes of 104 patients undergoing tubuloplasty were collected from December 2007 to March 2014. Intraocular pressure (IOP), number of glaucoma medication, visual acuity, complications, adjuvant therapy (laser retrocapillary or glaucoma) and success rate were recorded. IOP ≤ 21 mmHg No additional medication for complete success, IOP ≤ 21 mmHg Partially successful with or without glaucoma. Results: The mean preoperative IOP was 27.5 ± 9.2 mmHg and the postoperative average IOP was 14.5 ± 6.6 mmHg (P <0.001). The average preoperative visual acuity was 0.42 ± 0.4, postoperative was 0.32 ± 0.4 (P = 0.726). Partially successful 106 eyes (86.9%), completely successful 62 eyes (50.8%). Forty-three eyes (35.2%) underwent laser angle puncture and 49.1% under glaucoma. Postoperative average follow-up was 27.29 ± 16.78 (1 ~ 79) mo. Conclusions: The incidence of complications of tubulointerstitial angioplasty is low and the visual acuity is stable after operation. It is a safe choice. Postoperative laser angle anterior chamber angle puncture can improve the success rate of operation. Mitomycin C for tubulointerstitial role needs further in-depth comparative study.