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血管紧张素Ⅱ(AngⅡ)可刺激多种细胞分泌多种炎症因子,炎症与动脉粥样硬化存在高度相关性。多种细胞因子可诱导产生炎症标志物,炎症因子与炎症标志物直接参与动脉粥样硬化的形成,同时也介导甚至加强AngⅡ的致动脉粥样硬化作用。在AngⅡ、炎症因子、炎症标志物之间可能存在着一种复杂的网状联系,AngⅡ是这个网状联系的结点之一,具有关键作用;尚不能确定一种炎症因子或炎症标志物可作为这个网状联系的结点。在动脉粥样硬化性疾病的预防和治疗中对AngⅡ和炎症的抑制可获得良好的效果。
Angiotensin Ⅱ (Ang Ⅱ) can stimulate a variety of cells to secrete a variety of inflammatory factors, inflammation and atherosclerosis are highly correlated. A variety of cytokines can induce the production of inflammatory markers. Inflammatory cytokines and inflammatory markers are directly involved in the formation of atherosclerosis, and at the same time mediate and even enhance the atherogenic effect of Ang II. AngⅡ, inflammatory factors, inflammatory markers may exist between a complex network of contacts, Ang Ⅱ is one of the nodes of this network, has a key role; is still not sure whether an inflammatory cytokines or inflammatory markers As the node of this network connection. Inhibition of Ang II and inflammation in the prevention and treatment of atherosclerotic disease achieves good results.