Monitoring somatosensory evoked potentials in spinal cord ischemia-reperfusion injury

• 作 者: Yiming Ji Bin Meng Chenxi Yuan
• 机 构: Department of 0rthopedic Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2013年33期
• 关键词: neural regeneration spinal cord injury somatosensory evoked potentials spinal co
• 基金项目: This study was supported by the National Natural Science Foundation of China;the Natural Science Foundation of Jiangsu Province in China;Jiangsu Province Science and Technology Support Program (Social

It remains unclear whether spinal cord ischemia-reperfusion injury caused by ischemia and other non-mechanical factors can be monitored by somatosensory evoked potentials. Therefore, we monitored spinal cord ischemia-reperfusion injury in rabbits using somatosensory evoked potential detection technology. The results showed that the somatosensory evoked potential latency was significantly prolonged and the amplitude significantly reduced until it disappeared during the period of spinal cord ischemia. After reperfusion for 30-180 minutes, the amplitude and latency began to gradual y recover; at 360 minutes of reperfusion, the latency showed no significant difference compared with the pre-ischemic value, while the somatosensory evoked potential amplitude in-creased, and severe hindlimb motor dysfunctions were detected. Experimental findings suggest that changes in somatosensory evoked potential latency can reflect the degree of spinal cord ischemic injury, while the amplitude variations are indicators of the late spinal cord reperfusion injury, which provide evidence for the assessment of limb motor function and avoid iatrogenic spinal cord injury.