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探讨中药消痔灵注射液对肝肿瘤的治疗价值和毒副作用。将SD大鼠35只,分为5组,经肝动脉注射不同剂量消痔灵注射液,观察大鼠生存情况。另取SD大鼠39只,建立Walker256肝脏移植瘤模型,分为3组,分别经肝动脉注射生理盐水、阿霉素碘油乳剂、消痔灵注射液,比较治疗后肝内肿瘤体积大小的变化及各组荷瘤大鼠的生存期。结果:消痔灵注射液较大剂量可使肝脏大片状坏死,影响生存;而5mg/kg剂量组大鼠可长期生存,肝脏肉眼无明显变化。治疗后肿瘤体积比较,阿霉素碘油组、消痔灵液组体积均明显减小,与生理盐水组比较有显著性差异(P<0.01)。在生存期方面,消痔灵液组平均生存期高达(47.67±9.22)d,与生理盐水组和阿霉素碘油组比较与有显著性差异(P<0.01)。结论:合适剂量的消痔灵注射液经肝动脉灌注对大鼠移植性肝肿瘤有一定的抑制作用,能够延长荷瘤大鼠的生存期。
To explore the therapeutic value and side effects of traditional Chinese medicine Xiaozhiling Injection on liver tumors. Thirty-five Sprague-Dawley rats were divided into five groups. The rats were injected with different doses of Xiaozhiling injection through the hepatic artery to observe the survival of rats. Another 39 SD rats were established. Walker 256 liver xenograft model was established and divided into 3 groups. The rats were injected with normal saline, doxorubicin lipiodol emulsion and Xiaozhiling injection through the hepatic artery. The volume of intrahepatic tumor volume Changes and survival of each group of tumor-bearing rats. Results: The larger dose of Xiaozhiling Injection could cause large necrosis of the liver and affect survival. However, the rats in 5mg / kg dose could survive for a long time, and there was no significant change in the naked eye of the liver. Compared with the normal saline group, the volume of tumor in the treated group was significantly decreased (P <0.01). In terms of survival, the average survival time of Xiaoizhilingling liquid group was as high as (47.67 ± 9.22) days, which was significantly different from that of saline group and doxorubicin lipiodol group (P <0.01). Conclusion: The appropriate dose of Xiaozhiling injection through hepatic artery perfusion on rat liver transplantation have some inhibitory effect, can prolong the survival of tumor-bearing rats.