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目的探讨乙型肝炎患者前S1抗原(PreS1 Ag)、HBV-DNA与HBeAg之间的关系。方法对来我院就诊的240例乙型肝炎(简称乙肝)患者,进行了PreS1 Ag、HBV-DNA和HBeAg检测,对其相关性进行分析。结果 140例乙肝HBeAg阳性患者,PreS1 Ag和HBV-DNA的阳性率分别为95.0%和90.0%。100例乙肝HBeAg阴性患者,PreS1 Ag和HBV-DNA的阳性率分别为38.0%和36.0%。HBeAg阳性患者血清的PreS1 Ag和HBV-DNA的阳性率明显高于HBeAg阴性患者。结论 PreS1 Ag和HBV-DNA几乎同时出现,均能较准确的反映HBV复制状态。在PreS1 Ag和HBV-DNA水平方面,HBeAg阳性标本含量明显高于阴性标本。
Objective To investigate the relationship between PreS1 Ag, HBV-DNA and HBeAg in hepatitis B patients. Methods PreS1 Ag, HBV-DNA and HBeAg were detected in 240 patients with hepatitis B (referred to as hepatitis B) who came to our hospital for treatment, and their correlations were analyzed. Results The positive rates of PreS1 Ag and HBV-DNA in 140 cases of HBeAg positive patients were 95.0% and 90.0%, respectively. The positive rates of PreS1 Ag and HBV-DNA in 100 cases of HBeAg-negative patients were 38.0% and 36.0%, respectively. The positive rates of serum PreS1 Ag and HBV-DNA in HBeAg-positive patients were significantly higher than those in HBeAg-negative patients. Conclusions Both PreS1 Ag and HBV-DNA appear almost simultaneously, which can reflect HBV replication status more accurately. In PreS1 Ag and HBV-DNA levels, HBeAg positive specimens were significantly higher than the negative specimens.