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引入Ca2+、Fe3+、Zn2+、Mn2+等金属离子和氨基酸、柠檬酸、乳酸等小分子配体建立了Pu4+在人体血浆、胃液、组织液、细胞液等主要体液中的金属离子-小分子配体热力学平衡模型.利用该模型研究了正常生理条件下Pu(Ⅳ)在各体液中的存在形态以及pH值和[Pu]改变对Pu(Ⅳ)形态的影响.结果表明,血浆中的低浓度Pu(Ⅳ)易以Pu(OH)4(aq)的形态蓄积在肝脏中,钚浓度升高则形成沉淀难以排出;胃液中的Pu(Ⅳ)可大量进入血液中,但胃液pH值升高可实现钚的促排;组织液中钚会沉积在骨骼无机表面;高浓度Pu(Ⅳ)对大多数细胞有极高毒性;随着尿液的pH值增大,沉积的Pu(OH)4(s)会对肾脏造成损伤;胰液中的Pu(Ⅳ)的形态随着pH值改变而发生显著变化,而胆汁中高钚含量的Pu(Ⅳ)易滞留在肝脏内;在正常汗液pH值波动范围内,Pu(Ⅳ)易进入人体,从而对钚操作人员的健康产生危害.
The introduction of metal ions such as Ca2 +, Fe3 +, Zn2 + and Mn2 + and small molecule ligands such as amino acid, citric acid and lactic acid have established the thermodynamic equilibrium of metal ion-small molecule ligands in the body fluids of human plasma, gastric juice, tissue fluid, The model was used to study the existence of Pu (Ⅳ) in various body fluids and the effect of pH and Pu on the morphology of Pu (Ⅳ) under normal physiological conditions.The results showed that the low concentration of Pu (Ⅳ) ) Tends to accumulate in the liver in the form of Pu (OH) 4 (aq), which makes the formation of precipitate difficult to be excreted when the concentration of plutonium is increased. Pu (Ⅳ) in gastric juice can enter the blood in large quantities, Of Pu (Ⅳ) is highly toxic to most cells; as the urine pH increases, the deposited Pu (OH) 4 (s) will be (Ⅳ) in pancreatic juice changed significantly with the change of pH value, but Pu (Ⅳ) in the bile with high plutonium content could easily stay in the liver. In the range of normal sweat pH fluctuation, Pu (IV) is easily accessible to the human body, thereby jeopardizing the health of plutonium operators.