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在过去30年里儿童哮喘的发病率快速增长,而在同一时期包括邻苯二甲酸酯在内的环境化学物质的污染状况也越来越严重,这提示,邻苯二甲酸酯的暴露可能与儿童哮喘的高发有关。本文概述邻苯二甲酸酯的儿童内暴露状况与儿童哮喘发病情况之间的关系。其中,邻苯二甲酸酯儿童暴露与过敏性疾病的流行病学研究,为儿童哮喘的环境归因研究提供了一定的线索和研究方向;相关的动物实验和体外细胞实验,为探索邻苯二甲酸酯暴露所致包括过敏性哮喘在内的健康损害及可能的机制提供了一定的科学依据。虽然目前的研究显示,邻苯二甲酸酯暴露在哮喘发作过程中起到了佐剂的作用,但对于研究结果存在不一致性未得到明确结论。因此,在未来的研究中仍需要继续探索邻苯二甲酸酯对儿童罹患哮喘的影响,并进一步分析其可能的作用机制。
The incidence of asthma in children has increased rapidly in the past 30 years, while the pollution of environmental chemicals, including phthalates, has been aggravating over the same period, suggesting that exposure to phthalates May be related to the high incidence of asthma in children. This article outlines the relationship between exposure to childhood phthalates and childhood asthma. Among them, the epidemiological study of phthalate exposure and allergic diseases in children provides some clues and research directions for the environmental attribution of childhood asthma; related animal experiments and in vitro cell experiments, in order to explore the o-benzene Provided a scientific basis for the health damage and possible mechanisms including allergic asthma caused by the exposure of dicarboxylate. Although current research shows that phthalate exposure plays an adjuvant role in asthma attacks, there is no definitive conclusion about the inconsistencies in the results. Therefore, in future studies, we still need to continue to explore the impact of phthalates on asthma in children, and further analysis of its possible mechanism of action.