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目的:探究佝偻病患儿检测25羟维生素D3、胰岛素样生长因子-Ⅰ及超声骨密度的临床意义。方法:临床选择2015年5月至2016年4月佝偻病婴幼儿60例为观察组,同时选择体检健康婴幼儿60例作为研究对照,检测两组研究对象的25羟维生素D3、胰岛素样生长因子-Ⅰ及超声骨密度、骨碱性磷酸酶等临床指标水平;比较两组的25羟维生素D3、胰岛素样生长因子-Ⅰ及超声骨密度等临床指标水平。结果:观察组的25羟维生素D3、胰岛素样生长因子-Ⅰ及超声骨密度等临床指标水平显著低于对照组,差异有统计学意义(P<0.05)。而观察组的骨碱性磷酸酶指标显著高于对照组,差异有统计学意义(P<0.05)。结论:婴幼儿佝偻病的25羟维生素D3、胰岛素样生长因子-Ⅰ及超声骨密度等临床指标水平偏低,检测三项指标有助于婴幼儿佝偻病的早期诊断与治疗。
Objective: To investigate the clinical significance of 25 hydroxyvitamin D3, insulin-like growth factor-Ⅰ and ultrasound bone density in children with rickets. Methods: 60 cases of rickets in infants from May, 2015 to April, 2016 were selected as the observation group, and 60 healthy infants and young children were selected as the control group. The levels of 25-hydroxyvitamin D3 and insulin-like growth factor- Ⅰ and ultrasound bone mineral density, bone alkaline phosphatase and other clinical indicators; comparison of 25 hydroxyvitamin D3, insulin-like growth factor-Ⅰ and ultrasound bone mineral density and other clinical indicators. Results: The levels of 25 hydroxyvitamin D3, insulin - like growth factor - Ⅰ and ultrasound bone mineral density in the observation group were significantly lower than those in the control group (P <0.05). The observation group, bone alkaline phosphatase index was significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusion: The levels of 25 hydroxyvitamin D3, insulin-like growth factor-I and ultrasound bone density in infant rickets are low, and the detection of three indexes is helpful for the early diagnosis and treatment of infant rickets.