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在临床上,口服鱼肝油制剂品与钙剂目前仍然是治疗小儿佝偻病的主要药物之一。但越来越多的临床资料表明,在治疗中认为使用鱼肝油制剂仍有一些值得商榷之处。 1、维生素D的作用机制维生素D(食物) ↓维生素D_6(血液) ↓肝 25-OHD_3 ↓肾 1,25—(OH)_2D_3 ↓↓促进钙的吸收促进骨盐生长根据以上机理可知,仅有VitD发挥了这一生理作用。而我们在治疗中所用的鱼肝油制品含VitA的量均为VitD含量的10倍(国际单位)绝大多数患者并不件有缺乏VitA,因此,首先认为在选用药物上
Clinically, oral cod liver oil preparations and calcium are still one of the main drugs for the treatment of pediatric rickets. However, more and more clinical data show that in the treatment of the use of cod liver oil there are still some debatable. 1, the mechanism of vitamin D vitamin D (food) ↓ vitamin D_6 (blood) ↓ liver 25-OHD_3 ↓ kidney 1,25- (OH) _2D_3 ↓ ↓ promote calcium absorption and promote bone salt growth According to the above mechanism we can see that only VitD has played this physiological role. And the amount of vitamin A in cod liver oil products we use for treatment is 10 times greater than the VitD content (International Units) Most patients do not have a lack of VitA, so first of all that in the selection of drugs