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英国研究人员发现,TNF-a的高活性可能是导致顽固性哮喘患者气道高反应性的罪魁祸首。据统计,在全部哮喘患者中,约10％的患者的气道炎症非常顽固,对常规治疗,如吸入皮质类固醇激素类药物没有反应。鉴于TNF-a在炎症反应中发挥的重要
British researchers found that high activity of TNF-a may lead to airway hyperresponsiveness in patients with refractory asthma culprit. It is estimated that in about 10% of all asthmatics, airway inflammation is very stubborn and does not respond to conventional therapies such as inhaled corticosteroids. Given the importance TNF-a plays in the inflammatory response