The studies of PLGA nanoparticles loading atorvastatin calcium for oral administration in vitro and

• 作 者: Zhenbao Li Wenhui Tao Dong Zha
• 机 构: SchoolofPharmacy,TianjinMedicalUniversityCancerHospital,ChinaResourcesDouble-cranePharmaceuticalCo.,
• 出 处: 亚洲药物制剂科学(英文)
• 发表日期: 2017年3期
• 关键词: ATORVASTATIN calcium AC-PLGA-NPs Probe ultrasonication and EVAPORATION method OR
• 基金项目: financially supported by the Science and Technology Research Project of Liaoning Provincial Education Department L2013390.

A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium(AC) nanoparticles(AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental paramet