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有相当数量的药物,在唾液中的浓度和在血液中的浓度成一定的比例。由此探索从唾液中的药物浓度推断血浆中药物浓度的方法,从而利用唾液中的药物浓度来换算血浆中的药物浓度。唾液主要是从腮腺、舌下腺、腭下腺分泌到口腔中。它的pH 值范围是5～8,蛋白质含量不到血浆中蛋白质含量的1%,还含有少量的电解质和有机物。以往为了测定血浆中的药
There is a considerable amount of drug, which is proportional to the concentration in the saliva and in the blood. Thus, the method of deducing the concentration of drug in plasma from the concentration of drug in saliva was used to calculate the concentration of drug in plasma by using the drug concentration in saliva. Saliva is mainly from the parotid gland, sublingual gland, palatal gland secretion to the mouth. Its pH range is 5 to 8, protein content less than 1% of the plasma protein content, but also contains a small amount of electrolytes and organic matter. In the past for the determination of plasma drugs