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类风湿性关节炎(简称RA)是一种包括体液免疫和细胞免疫异常的自身免疫性疾病。在RA的治疗中,第一线药物是以非甾体抗炎剂为主的解热止痛药,第二线药物是青霉胺等缓解性药;对第一、二线药物治疗无效,且病情严重者,可考虑用糖皮质激素。激素治疗RA的机理不外乎其体液免疫抑制作用、抗炎作用和抑制成纤维细胞增生作用等。其应用指征为:①RA急性发作期,有发热,全身关节肿胀,用非甾体抗炎剂无效者;②有较严重关节外表现者(如间质性肺炎、心脏病变、血管炎及严重眼部并发症);③病程较长,病情较重,反复应
Rheumatoid arthritis (RA) is an autoimmune disease that includes humoral and cellular immune abnormalities. In the treatment of RA, the first line of drugs is non-steroidal anti-inflammatory agent-based antipyretic analgesics, the second line drug is penicillamine and other relieving drugs; the first and second-line drug treatment is invalid, and the condition is serious Those who may consider using glucocorticoids. The mechanism of hormone therapy RA is nothing more than its humoral immunosuppressive effects, anti-inflammatory effects and inhibition of fibroblast proliferation and so on. The indications for its use are: ① acute exacerbation of RA, fever, body joint swelling, non-use of non-steroidal anti-inflammatory agents ineffective; ② have more serious manifestations of joints (such as interstitial pneumonia, heart disease, vasculitis and severe Eye complications); ③ longer course, serious condition, should be repeated