论文部分内容阅读
研究了长期摄入大量的甘草或其天然成分甘草甜素对鼠肝脏依赖性细胞色素P450(CYP)药酶代谢的影响。为此,进一步研究了区域或立体选择性羟基化睾丸酮与高特异性底物联合应用的调节作用,以高特异性底物作为探针测定CYP异构体(CYP1A1、1A2、2B1、2E1和3A)。 不同组Swiss Albino CD1(雌雄不限)小鼠,口服日剂量的甘草(3.318或6.276mg/kg)或甘草甜素(240或480mg/kg)
The effects of long-term ingestion of large amounts of licorice or its natural component glycyrrhizin on the metabolism of liver-dependent cytochrome P450 (CYP) drug in mice were studied. To this end, further studies were conducted on the regulation of the use of a regional or stereoselective hydroxylated testosterone in combination with highly specific substrates, using highly specific substrates as probes for the determination of CYP isomers (CYP1A1, 1A2, 2B1, 2E1 and 3A). ). Different groups of Swiss Albino CD1 (male and female) mice, oral daily dose of licorice (3.318 or 6.276 mg/kg) or glycyrrhizin (240 or 480 mg/kg)