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对明确诊断的60例Ⅰ型变态反应患者(过敏性鼻炎及外源性哮喘患者各30例)的T 细胞亚群以及多项免疫指标进行分析,结果显示这类患者的 CD_3、CD_4、CD_8细胞百分率均有不同程度降低,其中以 CD_8降低和 CD_4/CD_8比值上升尤为显著并伴有大颗粒淋巴细胞百分率显著降低以及血清总 IgE 升高,其免疫学检验结果异常和临床症状以及过敏原皮肤试验的反应性高低相关。提示 CD_8、大颗粒淋巴细胞减低及功能低下可能是Ⅰ型变态反应患者免疫功能紊乱的重要环节。
T cell subsets of 60 patients with type Ⅰ allergic reaction (30 patients with allergic rhinitis and extrinsic asthma) and a number of immune indicators were analyzed. The results showed that CD_3, CD_4 and CD_8 cells The percentages of CD8 decreased and CD4 / CD8 increased especially significantly with the decrease of the percentage of large granulocyte lymphocytes and the increase of serum total IgE. The abnormality of immunological test results and clinical symptoms and allergen skin test Reactivity was correlated. It is suggested that CD_8, large granulocytopenia and hypofunction may be an important part of immune dysfunction in type Ⅰ allergic patients.