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目的探讨XAP辅酶Q10的安全性。方法按《食品安全性毒理学评价程序和方法》进行。结果 XAP辅酶Q10小鼠急性毒性试验LD50>15g/kg体重,为无毒级,小鼠骨髓嗜多染红细胞微核试验为阴性、小鼠精子畸形试验为阴性、Ames试验加与不加S9,均未呈现基因突变作用。大鼠30d喂养试验未观察到的有害作用剂量为1.33g/(kg·bw)。结论 XAP辅酶Q10无毒,无致突变性。
Objective To investigate the safety of XAP coenzyme Q10. Method according to “food safety toxicology evaluation procedures and methods”. Results XAP coenzyme Q10 mice acute toxicity test LD50> 15g / kg body weight, non-toxic grade, mouse bone marrow polychromatic erythrocyte micronucleus test was negative, sperm deformity test was negative, Ames test with and without S9, None of the mutations showed. The unacceptable dose of 1.33 g / (kg · bw) was not observed in the rat 30d feeding test. Conclusion XAP Coenzyme Q10 is non-toxic and non-mutagenic.