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目的观察腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症(ICP)的临床疗效。方法将125例ICP患者随机分成治疗组和对照组,对照组采用常规地塞米松静脉滴注加维生素来抑制DHEA-S产生E2,治疗组在此基础上加用腺苷胆氨酸静脉滴注。结果治疗组总有效率92%,高于对照组的70.7%,组间差异有统计学意义(P<0.05)。结论腺苷蛋氨酸用于治疗ICP效果显著,值得临床推广应用。
Objective To observe the clinical efficacy of adenosine methionine in the treatment of intrahepatic cholestasis of pregnancy (ICP). Methods A total of 125 patients with ICP were randomly divided into treatment group and control group. In the control group, conventional dexamethasone intravenous infusion and vitamin supplementation were used to inhibit the production of E2 by DHEA-S. On the basis of this, intravenous infusion of adenosine-choline . Results The total effective rate of the treatment group was 92%, which was higher than that of the control group (70.7%). The difference between the two groups was statistically significant (P <0.05). Conclusion adenosine methionine for the treatment of ICP significant effect, worthy of clinical application.