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应用反向间接ELISA IgM检测法和IFAT,对39例EHF病人的265份系列血清标本分别作EHF特异性IgM和IgG的检测。结果表明:重型EHF病人的IgM滴度明显高于轻、中两型;而IgG在三型之间的差异无显著性;两例IgM阴性的病人IgG亦为阳性;IgM在少尿期下降比IgG明显;在第2、3病日就能分别检测出IgM和IgG。作者认为,IgG不仅同样可以作为早期诊断的指标,而且可能较IgM更为全面;IgM与病情轻重关系密切;在疾病过程中检测IgM似可作为病情判断的特征之一,这一结果还间接地支持了免疫复合物致病说。
Using reverse indirect ELISA IgM assay and IFAT, EHF-specific IgM and IgG were detected in 265 serum samples from 39 patients with EHF. The results showed that IgM titers in patients with severe EHF were significantly higher than those in patients with mild and moderate EHF, while there was no significant difference in IgG among the three types. IgG was also positive in two patients with negative IgM. IgG was significant; IgM and IgG were detected on the 2nd and 3rd day. The author believes that IgG can not only be used as an indicator of early diagnosis, but also may be more comprehensive than IgM; IgM closely related to the severity of the disease; IgM in the course of the disease may be used as a feature of disease judgment, the result indirectly Supports immune complex pathogenesis.