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利用超临界流体制备微细颗粒是一门新兴的技术 ,将其中的气体抗溶剂 (GAS)法首次应用于制备乙基纤维素微粒 ,在系统的近临界和超临界范围进行了较为详细的实验研究 .在实验范围内 ,制得微粒的平均粒径为 2～ 15 μm .研究得到温度、压力、不同有机溶剂对微粒粒径及其分布的影响 ,并应用相平衡知识对结果进行了分析和讨论 .此研究为制备粒径较小 ,具有缓释、靶向、黏附等功能的乙基纤维素含药微粒做了准备 .
The use of supercritical fluid to prepare fine particles is an emerging technology. The gas-solvent-based (GAS) method was first applied to the preparation of ethylcellulose particles. A detailed experimental study was conducted on the near-critical and supercritical systems In the experimental range, the average diameter of the prepared particles is 2 ~ 15 μm.The effects of temperature, pressure and different organic solvents on the particle size and distribution of the particles were studied, and the results were analyzed and discussed with the knowledge of phase equilibrium This study is to prepare ethylcellulose-containing microparticles with smaller size, sustained release, targeting, adhesion and other functions.