论文部分内容阅读
目的评价血清C-反应蛋白(CRP)和降钙素原(PCT)在儿童感染性疾病诊断中的临床应用价值。方法选取2013年1月-2013年12月202例感染性疾病患儿,其中细菌感染组114例,非细菌感染组88例,另选正常对照组40例,采用免疫比浊法和发光法检测血清CRP与PCT水平。结果细菌感染组与非细菌感染组、对照组比较,CRP、PCT水平显著升高,差异有统计学意义(P<0.05);细菌感染组CRP阳性率为91.2%,PCT阳性率为60.5%,显著高于非细菌组和对照组,差异有统计学意义(P<0.05);CRP诊断细菌感染的敏感性为91.2%,显著高于PCT的60.5%,差异有统计学意义(P<0.05);CRP诊断细菌感染的特异性(93.8%)与PCT的特异性(96.9%)差异无统计学意义(P>0.05)。结论 CRP与PCT检测可作为儿童细菌感染性疾病的诊断和鉴别诊断的常规指标,联合检测CRP与PCT能提高诊断的敏感性和特异性,避免延误病情,有效降低不必要的抗生素使用。
Objective To evaluate the clinical value of serum C-reactive protein (CRP) and procalcitonin (PCT) in the diagnosis of infectious diseases in children. Methods Totally 202 children with infectious diseases from January 2013 to December 2013 were selected, including 114 cases of bacterial infection, 88 cases of non-bacterial infection and 40 cases of normal control. Immunoturbidimetry and luminescence Serum CRP and PCT levels. Results The levels of CRP and PCT in bacterial infection group were significantly higher than those in non-bacterial infection group and control group (P <0.05). The positive rate of CRP in bacterial infection group was 91.2% and the positive rate of PCT was 60.5% (P <0.05). The sensitivity of CRP in the diagnosis of bacterial infection was 91.2%, which was significantly higher than that in PCT (60.5%), the difference was statistically significant (P <0.05) The specificity of CRP in diagnosis of bacterial infection (93.8%) was not significantly different from that of PCT (96.9%) (P> 0.05). Conclusion The CRP and PCT tests can be used as routine indexes for the diagnosis and differential diagnosis of bacterial infectious diseases in children. Combined detection of CRP and PCT can increase the sensitivity and specificity of diagnosis, avoid delay of illness and effectively reduce the use of unnecessary antibiotics.