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肝脏在药物的代谢中起主要作用,因此非常容易受损害。特别是口服药,进入消化道先经门静脉到肝脏集中,然后进入全身血液循环内。但进入肝脏的药物,经过肝脏代谢,发生一系列生物化学转变,将一种药物转变成可溶形式如葡萄糖醛酸甙而便于排泄。当药物在肝细胞的浓度过高或药物转变成为有毒性代谢物,都有增加肝细胞毒性的危险。药物肝细胞毒反应的发生机理,一般认为有两种: 一、过敏机理:认为这是一种免疫反应,药物同肝细胞蛋白形成
The liver plays a major role in the metabolism of the drug and is therefore very vulnerable. Especially oral medication, enter the digestive tract through the portal vein to the liver, and then into the systemic blood circulation. However, drugs that enter the liver, after liver metabolism, undergo a series of biochemical changes that convert a drug into a soluble form such as glucuronidase for excretion. When drugs in the liver cells in the high concentration or drug into toxic metabolites, have increased the risk of hepatotoxicity. Drug hepatotoxic reaction mechanism, generally considered in two ways: First, the allergic mechanism: that this is an immune response, the formation of drugs and liver cell proteins