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目的:检测食管鳞状细胞癌组织中PTEN、血管内皮生长因子(VEGF)蛋白的表达。方法:应用免疫组织化学SP法检测49例食管鳞状细胞癌组织中PTEN、VEGF的表达。结果:PTEN蛋白的表达与癌组织分化程度、浸润深度及淋巴结转移有关(P<0.05),VEGF蛋白的表达与淋巴结转移有关(P<0.05);食管鳞状细胞癌组织中PTEN与VEGF的表达呈负相关(rs=-0.342)。结论:PTEN蛋白表达的降低或缺失可能上调VEGF的表达,从而促进肿瘤血管生成。2者在食管鳞状细胞癌的发生发展中可能起重要作用。
Objective: To detect the expression of PTEN and vascular endothelial growth factor (VEGF) in esophageal squamous cell carcinoma. Methods: Immunohistochemical SP method was used to detect the expression of PTEN and VEGF in 49 cases of esophageal squamous cell carcinoma. Results: The expression of PTEN protein was correlated with the degree of differentiation, depth of invasion and lymph node metastasis (P <0.05), and the expression of VEGF protein was correlated with lymph node metastasis (P <0.05). The expression of PTEN and VEGF in esophageal squamous cell carcinoma Was negatively correlated (rs = -0.342). Conclusion: The decrease or deletion of PTEN protein may up-regulate the expression of VEGF and promote tumor angiogenesis. 2 may play an important role in the occurrence and development of esophageal squamous cell carcinoma.