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作者将化疗失败的原因归纳为:1.方案不合理;2.药物毒性反应;3.自动过早停药;4.治疗过程中不规律用药或中断服药;5.开始化疗遇到耐药菌感染。失败原因主要是上述3、4两点。开始化疗的耐药菌感染,相对的并不重要。坦桑尼亚对经细菌学证实的病人治疗一年细菌学的失败率为15％。其中仅3％是方案不合理,9％是病人过早停药,INH原发耐药只占3％。因此失败原因是不规律用药。当然一个现代概念好方案的定义之一是最大限度地克服原发耐药的影响。先进国家已掌握标准化疗失败的不同原因,
The author summarizes the reasons for the failure of chemotherapy: 1. Irrational program; 2. Drug toxicity; 3. Automatic premature withdrawal; 4. Irregular medication or interruption of medication during the course of treatment; infection. The reason for the failure is mainly the above two points 3,4. Chemotherapy-resistant bacterial infections, the relative does not matter. One year bacteriological failure rate in Tanzania for bacteriologically validated patients was 15%. Of these, only 3% were unreasonable, 9% were prematurely discontinued, and INH primary only accounted for 3%. Therefore, the reason for failure is irregular medication. Of course one of the definitions of a good concept of a modern concept is to maximize the impact of primary resistance. Advanced countries have different reasons for the failure of standard chemotherapy,