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血浆睾丸酮(testosterone,T)中98%是结合型,且几乎全部是与睾丸酮-雌激素结合球蛋白(testoste-rone estrogen-binding globulin,TeBG)及白蛋白结合。现公认 TeBG 结合的 T 无生物活性,而白蛋白结合的 T(albumin bourd T,ABT)有无生物活性尚有争议。近来许多资料提示游离 T(FT)和 ABT 均有生物活性;ABT 可自由地与白蛋白解离而进入组织。作者所作的下述4项实验结果支持这一观点。①测定口服螺旋内酯25～200mg/d 1～3个月对6
98% of the plasma testosterone (T) is bound and almost exclusively bound to testosterone-binding globulin (TeBG) and albumin. It is recognized that TeBG-bound T has no biological activity and that albumin-bourd T (ABT) has no biological activity yet to be controversial. Many recent data suggest that both free T (FT) and ABT are bioactive; ABT is free to dissociate into albumin and enter the tissue. The authors’ following four experiments support this view. ① determination of oral hellactone 25 ~ 200mg / d 1 to 3 months on the 6