论文部分内容阅读
目的通过对高龄孕妇的羊水核型分析来探讨高龄孕妇胎儿染色体异常情况与年龄的相关性。方法对2011年1月到2015年6月来我院做产前诊断的1025例高龄孕妇进行羊膜腔穿刺抽取羊水做细胞培养并分析其核型。结果 1025例高龄孕妇中共检出异常核型69例,异常检出率为6.73%。在不同年龄组中,35-38岁,39-42岁,43岁以上孕妇的羊水染色体异常检出率分别是6.25%,7.17%,10.9%。结论随着高龄孕妇年龄的增长,胎儿染色体异常也明显增加。所以对高龄孕妇进行产前诊断,进行羊膜腔穿刺术,指导临床干预具有重要的价值。
Objective To investigate the relationship between fetal chromosomal abnormalities and age in advanced pregnant women through the amniotic fluid karyotype analysis of pregnant women. Methods From January 2011 to June 2015, 1025 elderly pregnant women who did prenatal diagnosis in our hospital were subjected to amniocentesis by amniocentesis for cell culture and their karyotypes were analyzed. Results A total of 1025 elderly pregnant women detected abnormal karyotypes in 69 cases, with an abnormality rate of 6.73%. In different age groups, the detection rates of amniotic fluid chromosome abnormalities in 35-38, 39-42 and 43-year-old pregnant women were 6.25%, 7.17% and 10.9% respectively. Conclusion As the age of pregnant women increases, fetal chromosomal abnormalities also increase significantly. Therefore, the elderly pregnant women for prenatal diagnosis of amniocentesis, guiding clinical intervention has an important value.