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目的:探讨抗环瓜氨酸肽(CCP)抗体和类风湿因子(RF)检测在类风湿关节炎(RA)诊断中的意义。方法:用ELISA方法检测248例(RA 112例,非RA 106例,及正常人30例)血清中的抗CCP抗体,免疫比浊法测RF,并比较抗CCP抗体与RF对于RA的敏感性和特异性。结果:抗CCP抗体在RA组患者血清中的阳性率49.1%,明显高于非RA组(3.94%)和正常对照组(0.0%),经t检验P<0.05。抗CCP抗体对诊断RA的敏感性和特异性分别为49.1%、93.2%,在112例确诊为RA患者的血清中抗CCP抗体与RF重叠阳性率为45.4%,两者含量呈正相关。结论:抗CCP抗体对RA具有很高的特异性,可视为新的RA血清学诊断指标,它与RA联合检测更能提高RA的早期诊断率。
Objective: To investigate the significance of anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) in the diagnosis of rheumatoid arthritis (RA). Methods: Anti-CCP antibodies in 248 serum samples (112 RA, 106 non-RA and 30 healthy individuals) were detected by ELISA. RF was detected by turbidimetry and the sensitivity of anti-CCP to RF was compared And specificity. Results: The positive rate of anti-CCP antibody in serum of RA patients was 49.1%, which was significantly higher than that of non-RA patients (3.94%) and normal control patients (0.0%), P <0.05 by t test. The sensitivity and specificity of anti-CCP antibody in the diagnosis of RA were 49.1% and 93.2% respectively. The positive rate of anti-CCP antibody and RF overlap in serum of 112 RA patients was 45.4%. Conclusion: The anti-CCP antibody has a high specificity for RA and may be regarded as a new diagnostic index of RA serology. Combined with RA, it can improve the early diagnosis rate of RA.