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目的:研究新鲜狼毒大戟根的化学成分。方法:利用硅胶柱色谱进行分离纯化,通过波谱性质鉴定化合物的结构。结果:分离得到14个化合物,分别鉴定为:2,4-二羟基-6-甲氧基-3-甲基苯乙酮(1)、12-deoxyphorbol-13-hexadecanoate(2)、没食子酸乙酯(3)、七叶内酯(4)、2,4-二羟基-6-甲氧基乙酰苯(5)、12-deoxyphorbol-13-acetate(prostratin)(6)、12-deoxyphorbol-13,20-diacetete(7)、jolkinolide B(8)、17-hydroxyjolkinolide B(9)、17-hydroxyjolkinol-ide A(10)、langduin C(11)、3-甲氧基对羟基苯甲酸(12)、没食子酸甲酯(13)、β-谷甾醇(14)。结论:化合物3、5、12、13为首次从狼毒大戟中分离得到。
Objective: To study the chemical constituents of Euphorbia pulcherrima root. Methods: The compounds were separated and purified by silica gel column chromatography and their structures were elucidated by spectroscopic properties. Results: Fourteen compounds were isolated and identified as 2,4-dihydroxy-6-methoxy-3-methylacetophenone (1), 12-deoxyphorbol-13-hexadecanoate Ester (3), esculetin (4), 2,4-dihydroxy-6-methoxyacetophenone (5), 12-deoxyphorbol-13-acetate , 20-diacetete (7), jolkinolide B (8), 17-hydroxyjolkinolide B (9), 17-hydroxyjolkinol- ide A (10), langduin C , Methyl gallate (13), β-sitosterol (14). Conclusion: Compounds 3, 5, 12 and 13 were isolated from Euphorbia euphorbia for the first time.