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冠心病发病率在相同年龄中男多于女,女性闭经前后还有很大的差异。而冠心病死亡率应用雌激素组比对照组低。据此可推断雌激素对动脉硬化的防治有一定作用。 ①雌激素与脂质:在临床上投予少量雌激素时,可见极低密度脂蛋白(VLDL)降低。一般认为是由于提高了脂蛋白酶活性所致。但若投予量增大则随着磷脂质的增加,出现VLDL、低密度脂蛋白(LDL)亦增加的倾向。 采用雌激素预防胆固醇所作的家兔动脉硬化负荷实验,可见血清胆固醇、尤其是VLDL成分减
The incidence of coronary heart disease in men and women at the same age more than women, women before and after menopause there is a big difference. The mortality of coronary heart disease application estrogen group than the control group. It can be concluded that estrogen on the prevention and treatment of atherosclerosis have a role. Estrogen and lipid: In the clinical administration of a small amount of estrogen, we can see very low density lipoprotein (VLDL) decreased. Is generally believed that due to increased lipoprotein enzyme activity. However, as the amount of administration increases, there is a tendency that VLDL and low density lipoprotein (LDL) also increase as phospholipid increases. Experimental study of atherosclerosis in rabbits using estrogen to prevent cholesterol shows that serum cholesterol, especially VLDL, is reduced by