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目的:探讨影响社区人群乙肝疫苗免疫效果的因素,为社区人群乙肝疫苗免疫效果的应用提供理论依据。方法:选取2013年4月-2016年5月社区人群中的90名儿童和少年作为此次研究对象,根据年龄进行分组,1-14岁的为儿童组30名,14-19岁的为少年组60名,采用固相放射免疫(RIA)法进行检测,检测出血清HBs Ag、抗-HBs和抗-HBc的结果,分析比较90名儿童和少年的乙肝血清标志阳性率情况,分析比较影响因素的相关参数。结果:90名儿童和少年的HBs Ag为2例,占比2.22%、抗-HBs为5例,占比5.56%和抗-HBc为56例,占比62.22%;影响90名儿童和少年的因素为母体HBs Ag的携带和乙肝疫苗接种情况,回顾系数分别为3.5124和-1.1152;OR分别为33.532和0.327;95%CI分别为14.385-78.151和0.25-0.447。结论:社区人群乙肝疫苗免疫效果显著,改善了群体免疫效果,乙肝疫苗的接种和母体HBs Ag携带情况是影响乙肝免疫效果的关键因素。
Objective: To explore the factors influencing the immune effect of hepatitis B vaccine in community population and to provide theoretical basis for the application of hepatitis B vaccine in community population. Methods: From April 2013 to May 2016, 90 children and adolescents from the community were selected as the subjects according to their age, 30 children aged from 1 to 14 and 14 to 19 years old 60 patients were tested for serum HBs Ag, anti-HBs and anti-HBc by using radioimmunoassay (RIA) method. The positive rates of serum hepatitis B markers in 90 children and adolescents were analyzed and compared Factors related to the parameters. Results: Among 90 children and adolescents, HBsAg was found in 2 cases (2.22%), anti-HBs in 5 cases (5.56%) and anti-HBc (56.22%), affecting 90 children and adolescents The factors were the carrier of HBsAg and vaccination of hepatitis B, the recall coefficients were 3.5124 and -1.1152 respectively; OR were 33.532 and 0.327 respectively; 95% CI was 14.385-78.151 and 0.25-0.447 respectively. Conclusion: Hepatitis B vaccine has significant immunization effect in community population, which can improve population immunity. Hepatitis B vaccination and maternal HBsAg carrier are the key factors affecting the effect of hepatitis B vaccine.