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目的回顾性分析脑恶性胶质瘤术后放化疗联合治疗临床疗效。方法选取2009年1月至2010年6月郑州颐和医院神经外科收治的胶质瘤患者92例,手术肉眼全切64例,部分切除28例。随机分为两组,A组采用手术切除后联合放化疗,B组手术切除后进行放疗。比较两组患者的近期、远期疗效以及不良反应发生率。结果 A组患者的近期有效率(67.4%~71.7%)高于B组(41.3%~47.8%),A组术后1、2、3年生存率分别为82.6%、50.0%和32.6%,也高于B组,具有统计学差异(P<0.05或P<0.01)。两组患者的不良反应发生率无差异。结论脑恶性胶质瘤术后放化疗联合治疗有较好疗效,不良反应较少,值得临床推广。
Objective To retrospectively analyze the clinical effects of combined chemotherapy and radiotherapy for malignant glioma after operation. Methods Ninety-two patients with glioma who were admitted to Department of Neurosurgery, Zhengzhou Yihe Hospital from January 2009 to June 2010 were enrolled in this study. All patients underwent gross resection in 64 cases and partial resection in 28 cases. Randomly divided into two groups, A group with surgical resection combined with radiotherapy and chemotherapy, B group after surgical excision radiotherapy. The short-term, long-term efficacy and incidence of adverse reactions in both groups were compared. Results The immediate effective rate (67.4% -71.7%) in group A was higher than that in group B (41.3% -47.8%). The 1, 2 and 3-year survival rates in group A were 82.6%, 50.0% and 32.6% Also higher than group B, with statistical difference (P <0.05 or P <0.01). There was no difference in the incidence of adverse reactions between the two groups. Conclusions The combination of radiotherapy and chemotherapy in patients with brain glioblastoma has better curative effect and fewer adverse reactions, which is worthy of clinical promotion.