Synthesis of Novel 1-Alkyl-2-chloro（alkoxy）-1H-indole 3-Carbaldehyde Oximes and Oxime-ethers（esters）

• 作 者: GAO Wen-tao GAO De-peng GUO Hu
• 机 构: InstituteofSuperfineChemicals
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2009年4期
• 关键词: 简便合成 吲哚酮 烷基化 甲醛肟 烷氧基 肟醚 肟酯 衍生物 Oxime Indole Vilsmeier-Haack reaction Williams
• 基金项目: Supported by the Natural Science Foundation of Liaoning Province, China（No.202142037）.

A convenient synthesis of 1-alkyl-2-chloro-1H-indole-3-carbaldehyde oximes(5a―5d) and 1-alkyl-2-phenoxy-1H-indole-3-carbaldehyde oximes(6a―6d) from 2-indolone was completed via the Vilsmeier-Haack reac-tion,with N-alkylation and oximation as the key steps